Hydrochloric Acid → HCID 71093738、化合物

HRID 1409711ノート

反応式

HRID 1409711 の反応式
C[O:2][C:3]([C:5]1(OC)[O:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][C:11]=2[F:18])[CH2:6]1)=[O:4].[OH-].[Na+].Cl>O1CCCC1>[C:16]([C:13]1[CH:14]=[CH:15][C:10]([C:7]2[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[O:9][N:8]=2)=[C:11]([F:18])[CH:12]=1)#[N:17]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 866861563-(4-Cyano-2-fluoro-phenyl)-5-methoxy-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester

生成物 1

HCID 71093738HCID 71093738、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 3-(4-cyano-2-fluoro-phenyl)-5-methoxy-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester (172 mg), 1N aqueous NaOH solution (2 mL), and tetrahydrofuran (5 mL) is stirred at room temperature for 3 h. The reaction mixture is acidified with 1 N hydrochloric acid (approximately pH 3) and concentrated in vacuo. The residue is triturated with water and the precipitate is filtered off and dried to give the title compound. LC (method 18): tR=0.38 min; Mass spectrum (ESI−): m/z=231 [M−H]−.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe residue is triturated with water
  3. filtrationthe precipitate is filtered off
  4. customdried

出典と根拠

ORDレコード
ord-2edb0fb4e3dd43f7aed6105505f3c49a
出典データセット
uspto-grants-2014_12
特許番号
US08921398B2

反応ノート

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