反応式
[CH3:1][O:2][CH2:3][CH:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[CH:10]=1>CO.[Pd]>[CH3:1][O:2][CH2:3][CH:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][CH:14]=1)[NH2:15]参加物
4
実験手順
The mixture of 2-(methoxymethyl)-1-(3-nitrophenyl)pyrrolidine (200 mg, 0.85 mmol), Pd/C (50 mg, 10%) in 50 mL of MeOH was stirred at room temperature for 18 hours under H2 atmosphere. Pd/C was filtrated off and the filtrate was concentrated under reduce pressure to give crude 3-(2-(methoxymethyl)pyrrolidin-1-yl)aniline (170 mg) as an oil. LC-MS: 207 [M+H]+, tR=1.15 min.
後処理
- filtrationPd/C was filtrated off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-522aa5c99bb349a4b7ff8428aab15cf4
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921383B2
関連ノート
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