HCID 58032133、化合物 → 4-(4-(3,4-Difluorophenyl)piperidin-1-yl)-3,5-difluoroaniline

HRID 1411418ノート

反応式

HRID 1411418 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]=[C:15]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[C:20]([F:25])[CH:19]=2)[CH2:14][CH2:13]1>C1COCC1.[Pd]>[F:25][C:20]1[CH:19]=[C:18]([CH:15]2[CH2:14][CH2:13][N:12]([C:3]3[C:4]([F:11])=[CH:5][C:6]([NH2:8])=[CH:7][C:2]=3[F:1])[CH2:17][CH2:16]2)[CH:23]=[CH:22][C:21]=1[F:24]

参加物

4

反応物 1

HCID 58032133HCID 58032133、化合物

生成物 1

HCID 580320614-(4-(3,4-Difluorophenyl)piperidin-1-yl)-3,5-difluoroaniline収率 100.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1-(2,6-difluoro-4-nitrophenyl)-4-(3,4-difluorophenyl)-1,2,3,6-tetrahydropyridine (0.67 g, 1.90 mmol) in THF (20 mL) was added 10% Pd on carbon (50 mg). The reaction flask was flushed with N2 gas, and the resulting mixture was vigorously stirred under 1 atm H2 gas for 24 hours. The mixture was filtered through diatomaceous earth and concentrated in vacuo to give the title compound as a solid (0.62 g, 100%).

後処理

  1. customThe reaction flask was flushed with N2 gas
  2. filtrationThe mixture was filtered through diatomaceous earth
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e62e3e82919c4a9e953242d9eec2dc25
出典データセット
uspto-grants-2014_12
特許番号
US08921514B2

反応ノート

読み込み中…