Water → 3-{[(2-Methoxyethyl)(methyl)amino]methyl}-5-methylbenzoic Acid

HRID 14126

反応式

HRID 14126 の反応式
[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:7][C:8]1[CH:9]=[C:10]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[C:11]([O:13]C)=[O:12])[CH3:6].O.[OH-].[Li+]>CO.O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:7][C:8]1[CH:9]=[C:10]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[C:11]([OH:13])=[O:12])[CH3:6]

参加物

6

反応物 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 21086148Methyl 3-{[(2-methoxyethyl)(methyl)amino]methyl}-5-methylbenzoate

生成物 1

HCID 210856713-{[(2-Methoxyethyl)(methyl)amino]methyl}-5-methylbenzoic Acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of methyl 3-{[(2-methoxyethyl)(methyl)amino]methyl}-5-methylbenzoate (180 mg, 0.72 mmol) in methanol (2 mL), tetrahydrofuran (1 mL), and water (1 mL) is added lithium hydroxide (302 mg, 7.2 mmol) and the reaction mixture stirred at room temperature for 2 h. The reaction mixture is concentrated under reduced pressure, dissolved in methylene chloride, filtered, and the filtrate concentrated under reduced pressure to provide the title compound. ESI MS m/z 238 [M+H]+.

後処理

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. dissolutiondissolved in methylene chloride
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-2b0f7a65980648e7bbf28ddfdfe6d821
出典データセット
uspto-grants-2010_06
特許番号
US07727997B2

関連ノート

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