5-Fluorouracil → 1,3-Bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione

HRID 1413196

反応式

HRID 1413196 の反応式
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[O:10]1[CH:14]=[CH:13][CH2:12][CH2:11]1>N1C=CC=CC=1>[O:10]1[CH2:11][CH2:12][CH2:13][CH:14]1[N:6]1[CH:7]=[C:2]([F:1])[C:3](=[O:9])[N:4]([CH:11]2[CH2:12][CH2:13][CH2:14][O:10]2)[C:5]1=[O:8]

参加物

4

反応物 2

HCID 33855-FluorouracilHCID 709342,3-Dihydrofuran

生成物 1

HCID 1249561,3-Bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
150 °C

実験手順

In 20.8 ml of pyridine were dissolved 5.2 g (40 m mol) of 5-fluorouracil and 14 g (200 m mol) of 2,3-dihydrofuran. The solution were heated at about 150° C. in a closed tubular reactor under agitation for 6 hours. After the reaction, the reaction mixture was concentrated to dryness under reduced pressure. The residue was dissolved in chloroform and the solution was passed through a column of silica gel. The column was eluated with chloroform and the effluent was concentrated to dryness under reduced pressure. The residue was washed with a small amount of petroleum ether to give the above-mentioned compound as colorless crystals.

後処理

  1. customAfter the reaction
  2. concentrationthe reaction mixture was concentrated to dryness under reduced pressure
  3. dissolutionThe residue was dissolved in chloroform
  4. concentrationthe effluent was concentrated to dryness under reduced pressure
  5. washThe residue was washed with a small amount of petroleum ether

出典と根拠

ORDレコード
ord-2992a554a28e4ff7a9ce0121c7aa404d
出典データセット
uspto-grants-1981_02
特許番号
US04249006

関連ノート

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