Nitric Acid → 5-Methyl-2-phenyl-1h-imidazole-4-carbaldehyde
反応式
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][OH:14].[N+]([O-])(O)=O>O.[OH-].[Na+]>[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH:13]=[O:14]参加物
5
実験手順
A 102.1 gm. portion of 5-methyl-2-phenyl-4-imidazolemethanol is dissolved in 765 ml. of concentrated HNO3. The solution is cooled in an ice bath and allowed to stand for 16 hours. The solution is heated on a steam bath for 30 minutes, diluted with 2.3 liters of water and neutralized with 50% NaOH while cooling in an ice bath. The solid is collected, dried, recrystallized from 200 ml. of ethanol and then from 1 liter of 1:2 ethanol:water giving the desired product, m.p. 102°14 115° C.
後処理
- temperatureThe solution is cooled in an ice bath
- temperatureThe solution is heated on a steam bath for 30 minutes
- temperaturewhile cooling in an ice bath
- customThe solid is collected
- customdried
- customrecrystallized from 200 ml
- custom102°14 115° C.
出典と根拠
- ORDレコード
- ord-3ec550555756455b9a1c25da691c8198
- 出典データセット
- uspto-grants-1981_02
- 特許番号
- USRE030511
反応ノート
読み込み中…