Ethyl Bromide → 5-(Ethylamino)-2-methylphenol

HRID 1415078ノート

反応式

HRID 1415078 の反応式
[CH2:1](Br)[CH3:2].[NH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:12])=[C:9]([OH:11])[CH:10]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C.O>[CH2:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:12])=[C:9]([OH:11])[CH:10]=1)[CH3:2]

参加物

6

反応物 3

HCID 6332Ethyl BromideHCID 10340Sodium CarbonateHCID 178185-Amino-2-methylphenol

生成物 1

HCID 158012485-(Ethylamino)-2-methylphenol

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

88.6 gm of ethyl bromide were added to a solution of 50 gm of 5-amino-2-methylphenol in 250 ml of ethanol; and the mixture was refluxed for four hours. After the solution had cooled, it was diluted with 1.2 liters of water and was made weakly alkaline with sodium carbonate. After repeated extraction with ether, the ether extracts were dried and concentrated. The residue was recrystallized from ethanol, and had a melting point of 128° C to 129° C.

後処理

  1. temperatureand the mixture was refluxed for four hours
  2. temperatureAfter the solution had cooled
  3. extractionextraction with ether
  4. dry with materialthe ether extracts were dried
  5. concentrationconcentrated
  6. customThe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-2d62aeab36f94fec92bdcf214f0008ec
出典データセット
uspto-grants-1977_01
特許番号
US04003699

反応ノート

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