N-Methyl-D-glucamine → N-Methyl-D-glucamine

HRID 1415535

反応式

HRID 1415535 の反応式
[CH3:1][NH:2][CH2:3][C@@H:4]([C@H:6]([C@@H:8]([C@@H:10]([CH2:12][OH:13])[OH:11])[OH:9])[OH:7])[OH:5].[CH3:14][C:15]1([CH3:38])[S:19][C@@H:18]2[C@H:20]([NH:23][C:24]([C@H:26]([NH2:34])[C:27]3[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=3)=[O:25])[C:21](=[O:22])[N:17]2[C@H:16]1[C:35]([OH:37])=[O:36].O.O.O>O>[CH3:1][NH:2][CH2:3][C@@H:4]([C@H:6]([C@@H:8]([C@@H:10]([CH2:12][OH:13])[OH:11])[OH:9])[OH:7])[OH:5].[CH3:14][C:15]1([CH3:38])[S:19][C@@H:18]2[C@H:20]([NH:23][C:24]([C@H:26]([NH2:34])[C:27]3[CH:28]=[CH:29][C:30]([OH:33])=[CH:31][CH:32]=3)=[O:25])[C:21](=[O:22])[N:17]2[C@H:16]1[C:35]([OH:37])=[O:36]

参加物

5

反応物 2

HCID 8567N-Methyl-D-glucamineHCID 62883Amoxicillin Trihydrate

生成物 2

HCID 8567N-Methyl-D-glucamineHCID 33613Amoxicillin

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

3 G. of N-methyl-D-glucamine are added to a suspension of 6 g. of amoxicillin trihydrate in 80 ml. of water and stirred at 5° C. Insoluble material is fitered off under suction and the resulting filtrate is lyophilized. There is thus obtained the N-methyl-D-glucamine salt of amoxicillin. Melting point: about 160° C. (decomposition). [α]D25 = + 133° (c =1 in water).

出典と根拠

ORDレコード
ord-4bb8520051cd446fad35e01eb9c612fa
出典データセット
uspto-grants-1977_01
特許番号
US04005214

関連ノート

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