8-Methyl-7-nitroquinoline → HCID 14115670、化合物

HRID 1416897ノート

反応式

HRID 1416897 の反応式
[CH3:1][C:2]1[C:3]([N+:12]([O-])=O)=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:12][C:3]1[C:2]([CH3:1])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 2541658-Methyl-7-nitroquinolineHCID 2723923Ammonium formate

生成物 1

HCID 14115670HCID 14115670、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 8-methyl-7-nitroquinoline (1.8 g) in methanol (20 mL) is added palladium-on-carbon (10%, 0.45 g) and ammonium formate (2.77 g). The mixture is stirred at room temperature for 30 minutes, then filtered on Celite, with a methanol wash of the solids. The filtrate is rotary evaporated and the residue partitioned between water and methylene chloride. The organic layer is dried over potassium carbonate, filtered and rotary evaporated to afford 7-amino-8-methylquinoline as a yellow solid.

後処理

  1. filtrationfiltered on Celite, with a methanol
  2. washwash of the solids
  3. customThe filtrate is rotary evaporated
  4. customthe residue partitioned between water and methylene chloride
  5. dry with materialThe organic layer is dried over potassium carbonate
  6. filtrationfiltered
  7. customrotary evaporated

出典と根拠

ORDレコード
ord-b220c06f3c6042068270816a5513ab96
出典データセット
uspto-grants-1999_06
特許番号
US05916900

反応ノート

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