Diethyl Ether → (6-Thien-2-ylpyrid-3-yl)methanol

HRID 1418424

反応式

HRID 1418424 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([C:12](O)=[O:13])=[CH:8][N:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)C.[OH-].[Na+]>C1COCC1.O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][OH:13])=[CH:8][N:7]=1

参加物

7

反応物 4

HCID 3283Diethyl EtherHCID 14798Sodium HydroxideHCID 154111446-(Thiophen-2-Yl)Pyridine-3-Carboxylic AcidHCID 21226445Aluminium lithium hydride

生成物 1

HCID 15411145(6-Thien-2-ylpyrid-3-yl)methanol

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-(thien-2-yl)-5-pyridinecarboxylic acid (0.333 g, 1.60 mmol) in THF (5 mL) at 0° C. is added 1.0M lithium aluminum hydride in diethyl ether (1.60 mL, 1.60 mmol) over 10 minutes. The reaction is allowed to stir at ambient temperature for 3 hours, cooled to 0° C., and water (0.10 mL), 4N aq. NaOH (0.10 mL), and water (0.30 mL) are added sequentially. The reaction is filtered through a pad of Celite and the filtrate is evaporated in vacuo. The residue is purified by chromatography to afford the title compound.

後処理

  1. temperaturecooled to 0° C.
  2. filtrationThe reaction is filtered through a pad of Celite
  3. customthe filtrate is evaporated in vacuo
  4. customThe residue is purified by chromatography

出典と根拠

ORDレコード
ord-9f09fb4afd6043c8889e9ac3c90d61b0
出典データセット
uspto-grants-1999_03
特許番号
US05883105

関連ノート

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