Chloride → 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-(dimethylaminomethyleneamino)imidazole-4-carbonyl chloride
反応式
[Cl-:1].[NH2:2][C:3]1[N:7]([C@@H:8]2[O:16][C@H:15]([CH2:17][O:18][C:19](=[O:21])[CH3:20])[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@@H:9]2[F:22])[CH:6]=[N:5][C:4]=1[C:23]([OH:25])=O>O1CCCC1>[C:12]([O:11][C@@H:10]1[C@@H:15]([CH2:17][O:18][C:19](=[O:21])[CH3:20])[O:16][C@@H:8]([N:7]2[C:3]([N:2]=[CH:6][N:7]([CH3:8])[CH3:3])=[C:4]([C:23]([Cl:1])=[O:25])[N:5]=[CH:6]2)[C@H:9]1[F:22])(=[O:14])[CH3:13]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
In step f, compound (35) is dissolved in tetrahydrofuran and reacted with N,N-dimethylchloroforminium chloride under ice-cooling. This reaction may be carried out in the same manner as in the step 12 of SYNTHETIC PROCESS CHART (A). By this reaction, 1-(3,5-di-O-acetyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-(dimethylaminomethyleneamino)imidazole-4-carbonyl chloride [compound(36)] is produced.