Hydrogen Peroxide → HCID 178448129、化合物

HRID 1419804ノート

反応式

HRID 1419804 の反応式
[C:1]([CH:4]1[CH2:9][CH2:8][C:7](=[O:10])[CH2:6][CH2:5]1)([CH3:3])=[CH2:2].CCC(C)[BH-](C(C)CC)C(C)CC.[Li+].[OH-].[Na+].OO>C1COCC1.C(Cl)Cl.O.C(O)C>[C:1]([C@@H:4]1[CH2:9][CH2:8][C@H:7]([OH:10])[CH2:6][CH2:5]1)([CH3:3])=[CH2:2]

参加物

9

反応物 4

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 5492914-(1-Methylethenyl)cyclohexanoneHCID 3611392Lithium tri-s-butylborohydride

生成物 1

HCID 178448129HCID 178448129、化合物

試薬・触媒・溶媒 4

HCID 702Ethanol溶媒HCID 962Water溶媒2 回HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

4.7 g (0.034 mol) of 4-isopropenylcyclohexanone dissolved in 35 ml of THF were added dropwise to 39 ml of a 1 molar solution at -78° C. of L-Selectride in THF. The mixture was subsequently stirred at -78° for 3 hours and then heated to room temperature, and 5 ml of H2O, 20 ml of ethanol, 15 ml of 6N NaOH and 17 ml of 35% strength H2O2 solution were added in succession. Water was added to the reaction solution, and extraction was carried out with methylene chloride. The combined methylene chloride phases are dried and concentrated. 37 g (78% of theory) of product remained as a colorless oil. The cis/trans mixture produced (>90% cis) was reacted further without additional purification.

後処理

  1. dry with materialThe combined methylene chloride phases are dried
  2. concentrationconcentrated
  3. customThe cis/trans mixture produced (>90% cis)
  4. customwas reacted further without additional purification

出典と根拠

ORDレコード
ord-348d230a333249368bd280ef1e33afb5
出典データセット
uspto-grants-1999_03
特許番号
US05889012

反応ノート

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