Hydrogen Peroxide → HCID 178429771、化合物

HRID 1419810ノート

反応式

HRID 1419810 の反応式
[CH3:1][C:2]1([CH:5]2[CH2:10][CH2:9][C:8](=[O:11])[CH2:7][CH2:6]2)[CH2:4][CH2:3]1.CCC(C)[BH-](C(C)CC)C(C)CC.[Li+].[OH-].[Na+].OO>C1COCC1.C(O)C.O>[CH3:1][C:2]1([C@@H:5]2[CH2:10][CH2:9][C@H:8]([OH:11])[CH2:7][CH2:6]2)[CH2:3][CH2:4]1

参加物

8

反応物 4

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 3611392Lithium tri-s-butylborohydrideHCID 541016014-(1-Methylcyclopropyl)cyclohexanone

生成物 1

HCID 178429771HCID 178429771、化合物

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 4.0 g (26.3 mmol) of 4-(1-methylcyclopropyl)cyclohexanone in 30 ml of THF was added dropwise at -78° C. to 5.5 g (29.0 mmol) of L-Selectride (1M in THF) and the mixture was subsequently stirred for 3 hours. It was then heated to room temperature, and 4 ml of H2O, 15 ml of ethanol, 11 ml of 6N NaOH and 13 ml of 35% strength H2O2 solution were added in succession to the reaction solution. This solution was left to stand overnight and then subjected to aqueous workup. Extraction was carried out with methylene chloride, and the extract was dried and concentrated. 3.4 g (86% of theory) were obtained of a colorless crystal powder, m.p.: 56° to 57° C.

後処理

  1. waitThis solution was left
  2. waitto stand overnight
  3. extractionExtraction
  4. customthe extract was dried
  5. concentrationconcentrated
  6. custom3.4 g (86% of theory) were obtained of a colorless crystal powder, m.p.: 56° to 57° C.

出典と根拠

ORDレコード
ord-52ab13d1969b4553b3185ba39d940fd3
出典データセット
uspto-grants-1999_03
特許番号
US05889012

反応ノート

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