反応式
[C:1]1([C:7]2[CH:8]=[C:9]([CH3:13])[CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:14]N1C(=O)CCC1=O.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[Br:14][CH2:13][C:9]1[CH:8]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:12]=[CH:11][CH:10]=1参加物
5
反応条件
- 温度
- 70 °C
実験手順
To a solution of 3-phenyltoluene (1.80 mL, 10.9 mmol) in carbon tetrachloride (50 mL) was added N-bromosuccinimide (2.124 g, 11.93 mmol) and the mixture heated to 70° C. AIBN (50 mg, 0.30 mmol) was added and the mixture refluxed for 30 mins. Additional AIBN was added (50 mg, 0.30 mmol) and the mixture refluxed for 16 hours. The reaction was cooled, filtered, and the solvent evaporated in vacuo. The residue was chromatographed (Silica gel, 5% EtOAc in hexanes) to afford the title compound as a white solid.
後処理
- temperaturethe mixture refluxed for 30 mins
- temperaturethe mixture refluxed for 16 hours
- temperatureThe reaction was cooled
- filtrationfiltered
- customthe solvent evaporated in vacuo
- customThe residue was chromatographed (Silica gel, 5% EtOAc in hexanes)
出典と根拠
- ORDレコード
- ord-0bc455fdad6c4568b19c27e59f766821
- 出典データセット
- uspto-grants-2000_06
- 特許番号
- US06080870
関連ノート
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