Sodium hydride → 5-(2-fluoropyridin-3-yl)-1-(2-furylsulfonyl)-1H-pyrrole-3-carbaldehyde

HRID 1426658ノート

反応式

HRID 1426658 の反応式
[F:1][C:2]1[C:7]([C:8]2[NH:12][CH:11]=[C:10]([CH:13]=[O:14])[CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[H-].[Na+].C1OCCOCCOCCOCCOC1.[O:32]1[CH:36]=[CH:35][CH:34]=[C:33]1[S:37](Cl)(=[O:39])=[O:38]>O1CCCC1.C(=O)([O-])O.[Na+]>[F:1][C:2]1[C:7]([C:8]2[N:12]([S:37]([C:33]3[O:32][CH:36]=[CH:35][CH:34]=3)(=[O:39])=[O:38])[CH:11]=[C:10]([CH:13]=[O:14])[CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

7

反応物 4

HCID 24758Sodium hydrideHCID 3633615-Crown-5HCID 2795072Furan-2-sulfonyl ChlorideHCID 58349828HCID 58349828、化合物

生成物 1

HCID 866239765-(2-fluoropyridin-3-yl)-1-(2-furylsulfonyl)-1H-pyrrole-3-carbaldehyde収率 83%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 516892Sodium Bicarbonate溶媒

実験手順

To a solution of 5-(2-fluoropyridin-3-yl)-1H-pyrrole-3-carbaldehyde (220 mg) in tetrahydrofuran (30 mL) was added sodium hydride (60% in oil, 84 mg) at room temperature and the mixture was stirred for 10 min. 15-Crown-5 (464 mg) was added dropwise, and the mixture was stirred for 5 min. Furan-2-sulfonyl chloride (263 mg) was added, and the mixture was further stirred for 30 min. The reaction mixture was diluted with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=1:1) and crystallized from diethyl ether to give the title compound as colorless crystals (yield 280 mg, 83%).

後処理

  1. stirringthe mixture was stirred for 5 min
  2. stirringthe mixture was further stirred for 30 min
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=1:1)
  8. customcrystallized from diethyl ether

出典と根拠

ORDレコード
ord-edc118d5cc464276a0a1b5c9e47714c5
出典データセット
uspto-grants-2015_01
特許番号
US08933105B2

反応ノート

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