Sodium Hydroxide → 4-Butyrylbenzoic acid

HRID 1427521ノート

反応式

HRID 1427521 の反応式
[C:1]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][CH:7]=1)(=[O:5])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>O1CCCC1.CO>[C:1]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 23143286Methyl 4-butyrylbenzoate

生成物 1

HCID 189835644-Butyrylbenzoic acid収率 65.1%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

Methyl 4-butyrylbenzoate (256.1 mg, 1.242 mmol) was dissolved in tetrahydrofuran (3 mL) and methanol (3.0 mL). 1N aqueous sodium hydroxide (3.73 mL) was added and the reaction mixture was heated to 50° C. for 3 h. The reaction mixture was then cooled to room temperature and concentrated. The crude residue was taken up in water and acidified to pH 5 by addition of 1N aqueous HCl. A colorless precipitate formed. The solids were filtered off and dried under vacuum to give 4-butyrylbenzoic acid (155.4 mg, 65%) as a colorless solid.

後処理

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. concentrationconcentrated
  3. additionacidified to pH 5 by addition of 1N aqueous HCl
  4. customA colorless precipitate formed
  5. filtrationThe solids were filtered off
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-51c475b6862948a1b4dd431105a01192
出典データセット
uspto-grants-2015_01
特許番号
US08933104B2

反応ノート

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