Ethyl 2-(3-methoxy-4-nitrophenyl)propanoate → Ethyl 2-(4-amino-3-methoxyphenyl)propanoate
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:12]([CH3:18])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>O1CCCC1.C(O)C.[Pd]>[NH2:9][C:8]1[CH:7]=[CH:6][C:5]([CH:12]([CH3:18])[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:4][C:3]=1[O:2][CH3:1]参加物
5
実験手順
To a stirred solution of ethyl 2-(3-methoxy-4-nitrophenyl)propanoate (683 mg, 2.697 mmol) in tetrahydrofuran and ethanol as co-solvent were added 10% Pd/C (70 mg). The mixture was charged with H2 (gas) balloon. The resulting mixture was stirred for 15 h, then filtered using celite. The filtrate removed in vacuo. The crude was purified by column chromatography. Ethyl 2-(4-amino-3-methoxyphenyl)propanoate (447 mg) was obtained as 74% yield.
後処理
- additionThe mixture was charged with H2 (gas) balloon
- filtrationfiltered
- customThe filtrate removed in vacuo
- customThe crude was purified by column chromatography
出典と根拠
- ORDレコード
- ord-7b4de9b56e794bddb08196e166bc4583
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08937092B2
反応ノート
読み込み中…