N-(2-methyl-4-nitrobenzyl)methanesulfonamide → N-(4-amino-2-methylbenzyl)methanesulfonamide
反応式
[CH3:1][C:2]1[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:3]=1[CH2:4][NH:5][S:6]([CH3:9])(=[O:8])=[O:7]>O1CCCC1.C(O)C.[Pd]>[NH2:14][C:12]1[CH:11]=[CH:10][C:3]([CH2:4][NH:5][S:6]([CH3:9])(=[O:8])=[O:7])=[C:2]([CH3:1])[CH:13]=1参加物
5
実験手順
To a stirred solution of N-(2-methyl-4-nitrobenzyl)methanesulfonamide (100 mg, 0.409 mmol) in tetrahydrofuran and ethanol as co-solvent were added 10% Pd/C (40 mg). The mixture was charged with H2 (gas) balloon. The resulting mixture was stirred for 24 h, then filtered using celite. The filtrate removed in vacuo. The crude was purified by column chromatography. N-(4-Amino-2-methylbenzyl)methanesulfonamide (61 mg) was obtained as 70% yield.
後処理
- additionThe mixture was charged with H2 (gas) balloon
- filtrationfiltered
- customThe filtrate removed in vacuo
- customThe crude was purified by column chromatography
出典と根拠
- ORDレコード
- ord-0e2af21424fc4ce3b20a39e69cbb1a37
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08937092B2
反応ノート
読み込み中…