Ethanesulfonyl chloride → N-(4-bromo-2-fluorobenzyl)ethanesulfonamide
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[C:4]([F:10])[CH:3]=1.[CH2:11]([S:13](Cl)(=[O:15])=[O:14])[CH3:12]>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][S:13]([CH2:11][CH3:12])(=[O:15])=[O:14])=[C:4]([F:10])[CH:3]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
(4-Bromo-2-fluorophenyl)methanamine (924 mg, 4.53 mmol) was dissolved in pyridine and ethane sulfonyl chloride (0.82 mL, 8.60 mmol) was added to the solution at 0° C. The mixture was stirred for 1 h at 0° C. Then, the mixture was quenched with 1N HCl and extracted with ethyl acetate. Drying over magnesium sulfate and evaporation of the ethyl acetate and purified by column chromatography gave N-(4-bromo-2-fluorobenzyl)-ethanesulfonamide in pure form (1.06 g, 79%).
後処理
- customThen, the mixture was quenched with 1N HCl
- extractionextracted with ethyl acetate
- dry with materialDrying over magnesium sulfate and evaporation of the ethyl acetate
- custompurified by column chromatography
出典と根拠
- ORDレコード
- ord-4ad33e7a18a64304ac8b533d122f3afb
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08937092B2
反応ノート
読み込み中…