1,1'-Carbonyldiimidazole → ethyl 2-(2-oxo-1H-imidazo[4,5-b]pyridin-3(2H)-yl)acetate
反応式
[NH2:1][C:2]1[C:3]([NH:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[N:4][CH:5]=[CH:6][CH:7]=1.C1N=CN([C:20](N2C=NC=C2)=[O:21])C=1>C1COCC1>[O:21]=[C:20]1[N:8]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[C:3]2=[N:4][CH:5]=[CH:6][CH:7]=[C:2]2[NH:1]1参加物
4
実験手順
To a solution of ethyl N-(3-aminopyridin-2-yl)glycinate (18 g) in THF (200 mL) was added CDI (15 g) at room temperature, and the mixture was stirred at room temperature overnight. The mixture was concentrated under reduced pressure. The residual crystals were washed with AcOEt to give the title compound (5.5 g).
後処理
- concentrationThe mixture was concentrated under reduced pressure
- washThe residual crystals were washed with AcOEt
出典と根拠
- ORDレコード
- ord-19e09549ed0b4f5cba06a8b00f9fdcd8
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08940758B2
反応ノート
読み込み中…