Methanol → 2-Methyl-3-oxo-3-(phenylamino)propanoic acid

HRID 1431285ノート

反応式

HRID 1431285 の反応式
[CH3:1][CH:2]([C:8](=[O:16])[NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:3]([O:5]CC)=[O:4].[OH-].[Na+].O.CO>C1COCC1>[CH3:1][CH:2]([C:8](=[O:16])[NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:3]([OH:5])=[O:4]

参加物

6

反応物 4

HCID 887MethanolHCID 962WaterHCID 14798Sodium HydroxideHCID 67509027Ethyl 2-methyl-3-oxo-3-(phenylamino)propanoate

生成物 1

HCID 126058802-Methyl-3-oxo-3-(phenylamino)propanoic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Prepared according to Procedure B using ethyl 2-methyl-3-oxo-3-(phenylamino)-propanoate (8.60 g, 39 mmol) and sodium hydroxide (2.00 g, 50 mmol) in THF (40.00 mL), water (10.00 mL, 555 mmol) and MeOH (10.00 mL) to afford product as a colorless solid, which was used without further purification. Mass Spectrum (ESI) m/e=192.1 [M−1].

後処理

  1. customPrepared
  2. customto afford product as a colorless solid, which
  3. customwas used without further purification

出典と根拠

ORDレコード
ord-00730ec492f948fd8708dd1610a637d8
出典データセット
uspto-grants-2015_01
特許番号
US08940724B2

反応ノート

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