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Sulfuric Acid → 2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo-piperazin-1-ylmethyl]-5,6,7,8-tetrahydro-thiazolo[4,5-c]azepin-4-one

HRID 1433076
ノート
印刷プレビュー

反応式

HRID 1433076 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:9]=[C:8]([S:10]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][C:20]4[S:21][C:22]5[CH2:28][CH2:27][CH2:26][C:25](=[O:29])[C:23]=5[N:24]=4)[C:15](=[O:30])[CH2:14]3)(=[O:12])=[O:11])[S:7][C:6]=2[CH:31]=1.S(=O)(=O)(O)O.[N-:37]=[N+]=[N-].[Na+].C([O-])([O-])=O.[K+].[K+]>C(Cl)(Cl)Cl.C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:9]=[C:8]([S:10]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][C:20]4[S:21][C:22]5[CH2:28][CH2:27][CH2:26][NH:37][C:25](=[O:29])[C:23]=5[N:24]=4)[C:15](=[O:30])[CH2:14]3)(=[O:11])=[O:12])[S:7][C:6]=2[CH:31]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 1118Sulfuric AcidHCID 11430Potassium CarbonateHCID 33557Sodium AzideHCID 670150242-[4-(6-chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo-piperazin-1-ylmethyl]-6,7-dihydro-5H-benzothiazol-4-one

生成物 1

HCID 670148362-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo-piperazin-1-ylmethyl]-5,6,7,8-tetrahydro-thiazolo[4,5-c]azepin-4-one

試薬・触媒・溶媒

2
HCID 6212Chloroform溶媒HCID 6344Dichloromethane溶媒

実験手順

2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-oxo-piperazin-1-ylmethyl]-6,7-dihydro-5H-benzothiazol-4-one (60 mg, 0.12 mmol) is dissolved in CHCl3 (4 mL) and sulfuric acid (0.5 mL) is added with vigorous stirring. Sodium azide (25 mg 0.4 mmol) is added and the reaction is stirred 1¾ h. The reaction is then added dropwise to a rapidly stirring mixture of K2CO3/H20/CH2Cl2. The organic phase is separated and washed with water, dried (MgSO4) and concentrated. The residue is purified by column chromatography (silica, 2% to 6% MeOH/CH2Cl2) to provide a mixture of two products.

後処理

  1. additionThe reaction is then added dropwise to
  2. stirringa rapidly stirring
  3. customThe organic phase is separated
  4. washwashed with water
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated
  7. customThe residue is purified by column chromatography (silica, 2% to 6% MeOH/CH2Cl2)
  8. customto provide
  9. additiona mixture of two products

出典と根拠

ORDレコード
ord-1f6e5c5f31934847adb4f29d1e8ce267
出典データセット
uspto-grants-2009_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07612075B2

反応ノート

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