Phosphine, triphenyl-, hydrobromide → [(6R*,9aS*)-6-(4-fluorophenyl)-4-oxooctahydropyrido[2,1-c][1,4]oxazin-3-yl]triphenylphosphonium bromide

HRID 1436092ノート

反応式

HRID 1436092 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[N:17]3[C@H:12]([CH2:13][O:14][CH:15](O)[C:16]3=[O:18])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[Br-:20].[C:21]1([PH+:27]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(#N)C>[Br-:20].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[N:17]3[C@H:12]([CH2:13][O:14][CH:15]([P+:27]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:16]3=[O:18])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 517696Phosphine, triphenyl-, hydrobromideHCID 69010340(6R*,9aS*)-6-(4-fluorophenyl)-3-hydroxyhexahydropyrido[2,1-c][1,4]oxazin-4-one

生成物 1

HCID 86612604[(6R*,9aS*)-6-(4-fluorophenyl)-4-oxooctahydropyrido[2,1-c][1,4]oxazin-3-yl]triphenylphosphonium bromide収率 98.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of (6R*,9aS*)-6-(4-fluorophenyl)-3-hydroxyhexahydropyrido[2,1-c][1,4]oxazin-4-one (26 mg) and triphenylphosphonium bromide (40 mg) in acetonitrile (3 mL) was heated under reflux for one hour and 30 minutes. The reaction solution was left to cool to room temperature, and then the solvent was evaporated under reduced pressure to obtain 57 mg of the title compound. The property value of the compound is as follows.

後処理

  1. temperatureunder reflux for one hour and 30 minutes
  2. waitThe reaction solution was left
  3. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-f5dafab9d2304369a11a48200c245442
出典データセット
uspto-grants-2009_11
特許番号
US07618960B2

反応ノート

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