Ethylene Glycol → 7-[3-(2-Hydroxyethoxy)-5-oxocyclopent-1-EN-1-YL]heptanoic acid

HRID 1439102

反応式

HRID 1439102 の反応式
Br[CH:2]1[CH2:6][C:5](=[O:7])[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:3]1.[CH2:17]([OH:20])[CH2:18][OH:19].N1C(C)=CC=CC=1C>O.[B-](F)(F)(F)F.[Ag+]>[OH:19][CH2:18][CH2:17][O:20][CH:2]1[CH2:6][C:5](=[O:7])[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:3]1

参加物

6

反応物 3

HCID 174Ethylene GlycolHCID 79372,6-LutidineHCID 130462774-Bromo-2-(6-carboxyhexyl)cyclopent-2-en-1-one

生成物 1

HCID 233299417-[3-(2-Hydroxyethoxy)-5-oxocyclopent-1-EN-1-YL]heptanoic acid

試薬・触媒・溶媒 2

HCID 159722Silver tetrafluoroborate触媒HCID 962Water溶媒

実験手順

To a stirred solution of 19.1 g. of crude 4-bromo-2-(6-carboxyhexyl)cyclopent-2-en-1-one (Example 93) in 310 ml. of ethylene glycol is added 15.6 g. (80 mmole) of silver fluoborate during 2 minutes. The exothermic reaction is controlled to give a temperature of 29° C., and after 1 minute the mixture is treated during 1 minute with 8.6 g. (80 mmole) of 2,6-lutidine. The mixture is stirred at ambient temperature for 2 hours, diluted with water, and filtered. The filtrate is diluted with saturated sodium chloride solution and extracted with ether. The extract is washed with half-saturated sodium chloride solution containing a little hydrochloric acid and saturated sodium chloride solution. The extract is dried over magnesium sulfate and concentrated. Column chromatograph of the residue on silica gel gives an oil, λ maxMeOH = 216 mμ (8350); ν max = 3340 (hydroxyl groups), 1700 (carbonyl groups), and 1620 cm -1 (olefin group).

後処理

  1. customThe exothermic reaction
  2. customto give a temperature of 29° C.
  3. additionafter 1 minute the mixture is treated during 1 minute with 8.6 g
  4. filtrationfiltered
  5. additionThe filtrate is diluted with saturated sodium chloride solution
  6. extractionextracted with ether
  7. washThe extract is washed with half-saturated sodium chloride solution
  8. additioncontaining a little hydrochloric acid and saturated sodium chloride solution
  9. dry with materialThe extract is dried over magnesium sulfate
  10. concentrationconcentrated
  11. customColumn chromatograph of the residue on silica gel gives an oil, λ maxMeOH = 216 mμ (8350)

出典と根拠

ORDレコード
ord-4e33cb807c654094920a24a08568b85c
出典データセット
uspto-grants-1977_11
特許番号
USRE029469

関連ノート

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