L-Leucine ethyl ester → HCID 131719291、化合物

HRID 1440074

反応式

HRID 1440074 の反応式
[C:1]([S:4][CH2:5][CH:6]([CH2:10][CH:11]([CH3:13])[CH3:12])[C:7](Cl)=[O:8])(=[O:3])[CH3:2].[NH2:14][C@H:15]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:16][CH:17]([CH3:19])[CH3:18].C(N(C(C)C)CC)(C)C>C(Cl)Cl>[C:1]([S:4][CH2:5][CH:6]([CH2:10][CH:11]([CH3:13])[CH3:12])[C:7]([NH:14][C@H:15]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:16][CH:17]([CH3:19])[CH3:18])=[O:8])(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 75971L-Leucine ethyl esterHCID 81531DiisopropylethylamineHCID 127690742-[(Acetylthio)methyl]-4-methylpentanoyl chloride

生成物 1

HCID 131719291HCID 131719291、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-Acetylthiomethyl-4-methylpentanoyl chloride and (L)-leucine, ethyl ester are reacted in methylene chloride in the presence of diisopropylethylamine at a temperature below 0° according to the procedure of Example 26 to yield (±)-N-[2-(acetylthiomethyl)-4-methyl-1-oxopentyl]-L-leucine, ethyl ester.

出典と根拠

ORDレコード
ord-5431d0014d5a41f09bda713037b05564
出典データセット
uspto-grants-1996_03
特許番号
US05496805

関連ノート

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