Thionyl Chloride → HCID 19973449、化合物

HRID 1440244ノート

反応式

HRID 1440244 の反応式
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH2:10]O)=[CH:6][N:5]2[CH:12]=1.S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:15].[Cl:15][CH2:10][C:7]1[CH:8]=[CH:9][C:4]2[N:5]([CH:12]=[C:2]([CH3:1])[N:3]=2)[CH:6]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 19973434HCID 19973434、化合物

生成物 1

HCID 19973449HCID 19973449、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

6.80 g of the 2-methylimidazo[1,2-a]pyridine-6-methanol prepared in the Preparative Example 16 was dissolved in 90 ml of chloroform, followed by the dropwise addition of 6.1 ml of thionyl chloride under stirring at room temperature. After 2 hours, the solvent was distilled off. Crude 6-chloromethyl-2-methylimidazo-[1,2-a]pyridine hydrochloride was obtained as a brown oil.

後処理

  1. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-ac7b6567428d4b3d9a3f0e2f323b612b
出典データセット
uspto-grants-1996_03
特許番号
US05498634

反応ノート

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