C[O:2][C:3](=O)[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([C:13]([F:16])([F:15])[F:14])=[CH:6][C:5]=1[N:17]=[C:18]=[O:19].[CH3:21][S:22]([NH:25][NH2:26])(=[O:24])=[O:23].[OH-].[Na+].Cl>C1COCC1>[N+:10]([C:8]1[CH:9]=[C:4]2[C:5](=[CH:6][C:7]=1[C:13]([F:16])([F:15])[F:14])[NH:17][C:18](=[O:19])[N:26]([NH:25][S:22]([CH3:21])(=[O:24])=[O:23])[C:3]2=[O:2])([O-:12])=[O:11]To a solution of 2-isocyanato-5-nitro-4-trifluoromethyl-benzoic acid methyl ester (110 mg, 0.379 mmol) in dry THF (1.7 mL) was added a solution of CH3SO2NHNH2 (41.7 mg, 0.379 mmol) in dry THF (0.6 mL) at r.t. The resultant mixture turned into a white suspension that was stirred for one hour. A 1 M aq NaOH solution (0.379 mL) was added and stirring of the clear solution was continued for 4 h. After addition of 2 M HCl solution (0.472 mL) and evaporation of the THF, the precipitate was filtered and dried at 50° C./0.1 mm yielding N-(6-nitro-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (114 mg, 81%) as a slightly yellow powder, m.p. 220-232° C. (decomp.). 1H-NMR (DMSO-d6, 400 MHz): 3.15 (s, 3H), 7.66 (s, 1H), 8.62 (s, 1H), 10.50 (s, 1H), 12.41 (s, 1H).
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