Azobisisobutyronitrile → 4-Bromomethyl-2-trifluoromethylbenzonitrile

HRID 1441685ノート

反応式

HRID 1441685 の反応式
[CH3:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[Br:14]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>ClC(Cl)(Cl)Cl>[Br:14][CH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:11])([F:12])[F:13])[CH:3]=1

参加物

5

反応物 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 27755974-Methyl-2-(trifluoromethyl)benzonitrile

生成物 1

HCID 591645854-Bromomethyl-2-trifluoromethylbenzonitrile収率 157.1%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

To a refluxing mixture of 5.0 g 4-Methyl-2-(trifluoromethyl)benzonitrile in 50 ml tetrachloromethane were added a mixture of 5.77 g N-bromosuccinimide and 1.77 g 2,2′-azobis(2-methylpropionitrile). The reaction mixture was heated under reflux for three hours. The reaction mixture was filtered through a pad of celite and the solvent was removed in vacuo to obtain 11.2 g crude 4-Bromomethyl-2-trifluoromethyl-benzonitrile (impurified with the dibromo product) as a white solid. This material was used without further purification.

後処理

  1. additionwere added
  2. temperatureThe reaction mixture was heated
  3. temperatureunder reflux for three hours
  4. filtrationThe reaction mixture was filtered through a pad of celite
  5. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-f1dbe9fd966e46c483507ca4ba370b6e
出典データセット
uspto-grants-2010_02
特許番号
US07655679B2

反応ノート

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