Sodium Hydroxide → 4-(Chloro(4-chlorophenyl)methyl)-1-methylpiperidine
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)O)=[CH:4][CH:3]=1.S(Cl)([Cl:19])=O.[OH-].[Na+]>C1(C)C=CC=CC=1>[Cl:19][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH:10]1[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]1参加物
5
実験手順
To a solution of 4-chlorophenyl 1-methylpiperidin-4-yl methanol 1.2 g (5.02 mmol) in toluene (5 ml) was added thionyl chloride (0.45 ml) dropwise. The resulting mixture was stirred at room temperature over night. The mixture was then made alkaline with NaOH solution and extracted with ethyl acetate (3×40). The combined organic solution was dried and concentrated to give 1.2 g of desired product.
後処理
- extractionextracted with ethyl acetate (3×40)
- customThe combined organic solution was dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-041276996f234298a025d98ae4560f94
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07659395B2
反応ノート
読み込み中…