2-Methoxybenzaldehyde → N-[(2-methoxyphenyl)methylidene]hydroxylamine

HRID 1443681ノート

反応式

HRID 1443681 の反応式
[OH-:1].[Na+].[CH:3](=O)[C:4]1[C:5]([O:10][CH3:11])=[CH:6][CH:7]=[CH:8][CH:9]=1.Cl.[NH2:14]O>O.C(O)C>[CH3:11][O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[CH:3]=[N:14][OH:1]

参加物

6

反応物 3

HCID 86582-MethoxybenzaldehydeHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 141489N-[(2-methoxyphenyl)methylidene]hydroxylamine収率 117.6%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

Add sodium hydroxide (8.50 g, 220 mmol) in water (150 mL) to a solution of o-anisaldehyde (25.0 g, 180 mmol) and hydroxylamine hydrochloride (15.4 g, 220 mmol) in ethanol (150 mL) and water (150 mL) at room temperature and stir the mixture for 3 hours. Acidify the mixture to pH 6 with 1 N HCl solution and collect the solids by vacuum filtration to provide 2-methoxybenzaldehyde oxime (32.0 g, 99%).

後処理

  1. customAcidify the mixture to pH 6 with 1 N HCl solution and collect the solids
  2. filtrationby vacuum filtration

出典と根拠

ORDレコード
ord-a1eae81e48e34359b08533b921a5cad0
出典データセット
uspto-grants-2010_02
特許番号
US07662771B2

反応ノート

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