1,3-Dibromopropane → 2-[4-(3-Bromopropoxy)phenyl]ethanol
反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Br:17][CH2:18][CH2:19][CH2:20]Br>C(#N)C>[Br:17][CH2:18][CH2:19][CH2:20][O:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][OH:8])=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 70 °C
実験手順
To a solution of 4-hydroxyphenethyl alcohol (4.37 g, 31.0 mmol) and potassium carbonate (6.55 g, 47.0 mmol) in acetonitrile (62.0 mL) was added 1,3 dibromopropane (31.0 mL, 316 mmol). The reaction mixture was heated to 70° C. for 12 hours and then cooled to room temperature, filtered and concentrated under vacuum. The resulting oil was purified by silica gel chromatography using a mixture of 4:1 hexanes and ethyl acetate to give the title compound (6.21 g) as a white solid.
後処理
- temperaturecooled to room temperature
- filtrationfiltered
- concentrationconcentrated under vacuum
- customThe resulting oil was purified by silica gel chromatography
- additiona mixture of 4:1 hexanes and ethyl acetate
出典と根拠
- ORDレコード
- ord-93f3d96d34ad4634b129237859851a50
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732441B2
反応ノート
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