Ethyl formate → Ethyl 2-[(2H-1,3-benzodioxol-5-yl)methyl]-3-oxopropanoate

HRID 1445306ノート

反応式

HRID 1445306 の反応式
[H-].[Na+].[CH2:3]1[O:11][C:10]2[CH:9]=[CH:8][C:7]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:6][C:5]=2[O:4]1.[CH:19](OCC)=[O:20]>O1CCCC1>[CH:19]([CH:13]([CH2:12][C:7]1[CH:8]=[CH:9][C:10]2[O:11][CH2:3][O:4][C:5]=2[CH:6]=1)[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:20]

参加物

5

反応物 3

HCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 81545Ethyl 1,3-benzodioxole-5-propionate

生成物 1

HCID 10060648Ethyl 2-[(2H-1,3-benzodioxol-5-yl)methyl]-3-oxopropanoate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

First, 42.4 g of 60% NaH was suspended in 500 ml of tetrahydrofuran (THF). 84.5 g (purity: 93.7% by weight) of ethyl 3-(3,4-methylenedioxyphenyl)-propionate was dissolved in 100 ml of THF and added dropwise to the suspension solution prepared above at room temperature. After the resultant suspension solution was raised in temperature to 40° C. and stirred for 15 minutes, 131 g of ethyl formate was added dropwise for 2.5 hours to the suspension solution and stirred for a further 3 hours.

後処理

  1. additionadded dropwise to the suspension solution
  2. customprepared above at room temperature
  3. stirringstirred for a further 3 hours

出典と根拠

ORDレコード
ord-98f38d7cc9aa4ea591aa80a17b083bf6
出典データセット
uspto-grants-2010_02
特許番号
US07666659B2

反応ノート

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