Lithium Hydroxide → (2Z)-3-Methylhepta-2,6-dienoic acid
反応式
[CH3:1]/[C:2](/[CH2:8][CH2:9][CH:10]=[CH2:11])=[CH:3]/[C:4]([O:6]C)=[O:5].[Li+].[OH-]>C1COCC1.O>[CH3:1]/[C:2](/[CH2:8][CH2:9][CH:10]=[CH2:11])=[CH:3]/[C:4]([OH:6])=[O:5]参加物
5
実験手順
A solution of the title compound from Example 20 (6.8 g, 32.5 mmol) in THF (150 mL) was treated with 1 N LiOH (100 mL) and water (125 mL) and stirred vigorously for 4 days. The mixture was diluted with water and washed twice with ether. The aqueous phase was taken to pH 1.5 by addition of 2N HCl and extracted three times with ether. The organic extracts were dried and the solvents evaporated to give the title compound (2.57 g, 56%) as a pale yellow oil.
後処理
- washwashed twice with ether
- additionThe aqueous phase was taken to pH 1.5 by addition of 2N HCl
- extractionextracted three times with ether
- customThe organic extracts were dried
- customthe solvents evaporated
出典と根拠
- ORDレコード
- ord-95275c8a89bf41fbbcba0190e95a8163
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07666861B2
反応ノート
読み込み中…