N-bromobutanimide → 2-Bromomethyl-4-tert-butyl-6-chloro-pyridine

HRID 1446720ノート

反応式

HRID 1446720 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([CH3:11])([CH3:10])[CH3:9])[CH:5]=[C:4]([CH3:12])[N:3]=1.[Br:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.CC(N=NC(C#N)(C)C)(C#N)C>[Br:13][CH2:12][C:4]1[CH:5]=[C:6]([C:8]([CH3:9])([CH3:11])[CH3:10])[CH:7]=[C:2]([Cl:1])[N:3]=1

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 601265994-Tert-butyl-2-chloro-6-methylpyridine

生成物 1

HCID 866343052-Bromomethyl-4-tert-butyl-6-chloro-pyridine収率 44.3%

試薬・触媒・溶媒 2

HCID 6547Azobisisobutyronitrile触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

Dissolve 2-chloro-6-methyl-4-tert-butyl-pyridine (3.00 g, 16.33 mmol), N-bromosuccinimide (3.20 g, 17.97 mmol) and AIBN (0.03 g, 0.16 mmol) in carbon tetrachloride (60 mL) and heat to reflux. After heating for 6 hours, stir the contents overnight at ambient temperature. The contents are then concentrated to dryness and dry loaded onto a silica plug and eluted with dichloromethane to obtain the title compound (1.90 g, 7.23 mmol). MS(ES), m/z 263 (M+1).

後処理

  1. temperatureheat to reflux
  2. temperatureAfter heating for 6 hours
  3. concentrationThe contents are then concentrated to dryness
  4. customdry
  5. washeluted with dichloromethane

出典と根拠

ORDレコード
ord-01f1f9d32d2449c4aa81d10a9882dbd7
出典データセット
uspto-grants-2010_02
特許番号
US07666879B2

反応ノート

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