Hydrogen Bromide → HCID 20550939、化合物

HRID 1447419ノート

反応式

HRID 1447419 の反応式
[C:1]([C:4]1[S:8][CH:7]=[C:6]([C:9]([NH2:11])=[O:10])[CH:5]=1)(=[O:3])[CH3:2].[BrH:12].BrBr>C(Cl)(Cl)Cl.C(O)(=O)C>[Br:12][CH2:2][C:1]([C:4]1[S:8][CH:7]=[C:6]([C:9]([NH2:11])=[O:10])[CH:5]=1)=[O:3]

参加物

6

反応物 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 205509375-Acetylthiophene-3-carboxamide

生成物 1

HCID 20550939HCID 20550939、化合物

試薬・触媒・溶媒 2

HCID 176Acetic Acid触媒HCID 6212Chloroform溶媒2 回

実験手順

A solution of 5-acetylthiophene-3-carboxamide (0.5 g) in chloroform at 50° was treated with hydrogen bromide in acetic acid (4 drops) and then bromine (0.15 ml) in chloroform (10 ml) dropwise over 30 min. The resulting pale yellow solution was washed with water (2×100 ml), dried and evaporated to small volume to deposit the title compound as a white solid (0.55 g) which recrystallised from water, m.p. 150°-157° (d).

後処理

  1. washThe resulting pale yellow solution was washed with water (2×100 ml)
  2. customdried
  3. customevaporated to small volume
  4. customrecrystallised from water, m.p. 150°-157° (d)

出典と根拠

ORDレコード
ord-e37ce2377dc84078a3014aa9c3f5b49e
出典データセット
uspto-grants-1982_02
特許番号
US04316907

反応ノート

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