Chloroform → Imidazo(1,2-a)pyridine

HRID 1447613ノート

反応式

HRID 1447613 の反応式
N[C:2]1[N:6]2[CH:7]=[C:8](SC3C=CC=CC=3)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.C(Cl)(Cl)Cl.COC(Cl)=O>C(N(CC)CC)C>[N:4]1[CH:3]=[CH:2][N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=12

参加物

5

反応物 3

HCID 6212ChloroformHCID 6586Methyl chloroformateHCID 53813641HCID 53813641、化合物

生成物 1

HCID 78960Imidazo(1,2-a)pyridine

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

A solution of 1.0 g. of 3-amino-6-(phenylthio) imidazo [1,2-a] pyridine in 25 ml. of chloroform containing 0.401 g. of triethyl amine is treated dropwise with 0.378 g. of methylchloroformate. The reaction mixture is stirred for 3 hours at room temperature. The chloroform is removed in vacuo and the residue is triturated with water. The solids are collected by filtration, washed well with water and dried. Recrystallization from dimethylformamide-ethane yields pure 3-(methoxycarbonylamino) 6-phenylthio) imidazo [1,2-a] pyridine m.p. 211°-215° C.

後処理

  1. customThe chloroform is removed in vacuo
  2. customthe residue is triturated with water
  3. filtrationThe solids are collected by filtration
  4. washwashed well with water
  5. customdried
  6. customRecrystallization from dimethylformamide-ethane

出典と根拠

ORDレコード
ord-52d58b88a6cd4441b8d01a1b74a867d1
出典データセット
uspto-grants-1979_12
特許番号
US04177274

反応ノート

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