Diboron → 3-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine

HRID 1447876ノート

反応式

HRID 1447876 の反応式
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18](O)=O)=[C:13]3[N:12]=[CH:11][CH:10]=2)[CH:4]=1.B#B>O1CCCC1>[CH3:18][C:17]1[CH:16]=[N:15][N:14]2[C:9]([C:5]3[CH:4]=[C:3]([C:2]([F:22])([F:1])[F:21])[CH:8]=[CH:7][CH:6]=3)=[CH:10][CH:11]=[N:12][C:13]=12

参加物

4

反応物 2

HCID 6328200DiboronHCID 103353477-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

生成物 1

HCID 233298353-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 0.01 mole of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid in tetrahydrofuran is added dropwise to a chilled (0° C.) solution of 0.02 mole of diborane in tetrahydrofuran. After standing overnight the mixture is poured onto ice and the product extracted into dichloromethane. The dichloromethane layer is washed with water, dried (MgSO4) and the solvent removed to give the product of the example.

後処理

  1. additionthe mixture is poured onto ice
  2. extractionthe product extracted into dichloromethane
  3. washThe dichloromethane layer is washed with water
  4. dry with materialdried (MgSO4)
  5. customthe solvent removed
  6. customto give the product of the example

出典と根拠

ORDレコード
ord-0ce4ee984eb843e694b0ffae2a5596be
出典データセット
uspto-grants-1979_12
特許番号
US04178449

反応ノート

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