Hydrochloric Acid → 7,8-Diamino-3-(4-chlorophenyl)-2-isopropyl-chromen-4-one

HRID 14489

反応式

HRID 14489 の反応式
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[C:10]2[C:5]([C:6](=[O:25])[C:7]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)=[C:8]([CH:15]([CH3:17])[CH3:16])[O:9]2)=[CH:4][CH:3]=1.Cl>CO.[Pd]>[NH2:1][C:2]1[C:11]([NH2:12])=[C:10]2[C:5]([C:6](=[O:25])[C:7]([C:18]3[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=3)=[C:8]([CH:15]([CH3:16])[CH3:17])[O:9]2)=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 597242787-Amino-3-(4-chlorophenyl)-2-isopropyl-8-nitro-chromen-4-one

生成物 1

HCID 687024427,8-Diamino-3-(4-chlorophenyl)-2-isopropyl-chromen-4-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

7-Amino-3-(4-chlorophenyl)-2-isopropyl-8-nitro-chromen-4-one (450 mg, 0.94 mmol) is suspended in methanol (5 ml). Concentrated hydrochloric acid (5 ml) is added. The mixture is placed under an atmosphere of argon, and 10% palladium on activated carbon (50 mg) is added. The reaction mixture is placed under an atmosphere of hydrogen and stirred at room temperature for 24 h. The mixture is filtered through a Celite pad, and the Celite pad is washed with methanol (3×30 ml). The filtrate and the washings are combined and evaporated to give a yellow solid.

後処理

  1. filtrationThe mixture is filtered through a Celite pad
  2. washthe Celite pad is washed with methanol (3×30 ml)
  3. customevaporated
  4. customto give a yellow solid

出典と根拠

ORDレコード
ord-0189d225b5614d789f5d04eee4b24eaf
出典データセット
uspto-grants-2010_06
特許番号
US07732435B2

関連ノート

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