Sodium Hydroxide → (3,4-Bis(difluoromethoxy)phenyl)methanol

HRID 1451923ノート

反応式

HRID 1451923 の反応式
[F:1][CH:2]([F:16])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH:13]([F:15])[F:14])[CH:7]=[O:8].[BH4-].[Na+].[OH-].[Na+]>C(O)C>[F:1][CH:2]([F:16])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH:13]([F:15])[F:14])[CH2:7][OH:8]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 145092693,4-Bis(difluoromethoxy)benzaldehyde

生成物 1

HCID 53484633(3,4-Bis(difluoromethoxy)phenyl)methanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3,4-Bisdifluoromethoxybenzaldehyde (26.2 g, 110 mmol) in absolute ethanol (150 mL) was treated with sodium borohydride (8.32 g, 220 mmol) under an argon atmosphere at room temperature for 0.5 h. Ten percent aqueous sodium hydroxide (130 mL) was added, the ethanol was removed in vacuo, the mixture was partitioned between ether and water and was etracted twice with ether. The organic extract was dried (magnesium sulfate) and evaporated to a pale yellow oil (26.4 g, 100%).

後処理

  1. customthe ethanol was removed in vacuo
  2. customthe mixture was partitioned between ether and water
  3. extractionThe organic extract
  4. dry with materialwas dried (magnesium sulfate)
  5. customevaporated to a pale yellow oil (26.4 g, 100%)

出典と根拠

ORDレコード
ord-8af9592a8fbd40bc9b0896e4e8df7e8b
出典データセット
uspto-grants-1997_02
特許番号
US05605923

反応ノート

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