3-Fluorobenzenesulfonyl Chloride → N-(3-cyano-1H-indazol-5-yl)-3-fluorobenzenesulfonamide

HRID 1452827

反応式

HRID 1452827 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[C:11]#[N:12].[F:13][C:14]1[CH:15]=[C:16]([S:20](Cl)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1>N1C=CC=CC=1>[C:11]([C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([NH:1][S:20]([C:16]3[CH:17]=[CH:18][CH:19]=[C:14]([F:13])[CH:15]=3)(=[O:22])=[O:21])[CH:3]=2)[NH:7][N:6]=1)#[N:12]

参加物

4

反応物 2

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 225673035-Amino-1H-indazole-3-carbonitrile

生成物 1

HCID 10064331N-(3-cyano-1H-indazol-5-yl)-3-fluorobenzenesulfonamide収率 84.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

N-(3-Cyano-1H-indazol-5-yl)-3-fluorobenzenesulfonamide can be obtained as described in Example 2 from 0.6 g of 5-amino-3-cyano-1H-indazole, 12 ml of pyridine and 0.73 g of 3-fluorobenzenesulfonyl chloride. 1 g of N-(3-cyano-1H-indazol-5-yl)-3-fluorobenzenesulfonamide is thus obtained in the form of a yellow solid melting at 227° C. (analysis C14H9FN4O2S % calculated C, 53.16; H, 2.87; F, 6.01; N, 17.71; O, 10.12; S, 10.14% found C, 52.86; H, 2.63; F, 5.67; N, 16.04).

出典と根拠

ORDレコード
ord-a0f1c1d559d7441da8a91da435bb53a7
出典データセット
uspto-grants-2009_01
特許番号
US07473701B2

関連ノート

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