Thionyl Chloride → 3-(3-Bromo-4-methoxyphenyl)propanoyl chloride

HRID 1455710ノート

反応式

HRID 1455710 の反応式
S(Cl)([Cl:3])=O.[Br:5][C:6]1[CH:7]=[C:8]([CH2:14][CH2:15][C:16]([OH:18])=O)[CH:9]=[CH:10][C:11]=1[O:12][CH3:13]>C(Cl)(Cl)Cl>[Br:5][C:6]1[CH:7]=[C:8]([CH2:14][CH2:15][C:16]([Cl:3])=[O:18])[CH:9]=[CH:10][C:11]=1[O:12][CH3:13]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 45476083-(3-Bromo-4-methoxyphenyl)propanoic acid

生成物 1

HCID 866051613-(3-Bromo-4-methoxyphenyl)propanoyl chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 102.4 g (0.86 mol) of thionyl chloride is added to a solution of 51.8 g (0.2 mol) of 3-(3-bromo-4-methoxyphenyl)propanoic acid in 700 ml of chloroform. The mixture is heated at reflux for 4 hours, and the solvent is then evaporated off. 53 g are obtained.

後処理

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 4 hours
  3. customthe solvent is then evaporated off
  4. custom53 g are obtained

出典と根拠

ORDレコード
ord-0ee2744e847249628c9e61bc778d8953
出典データセット
uspto-grants-2009_01
特許番号
US07482484B2

反応ノート

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