Ammonium formate → Ethyl 5-amino-1-ethyl-1H-indole-2-carboxylate

HRID 1455822ノート

反応式

HRID 1455822 の反応式
[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH2:18][CH3:19])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([N+:15]([O-])=O)=[CH:10][CH:9]=2)=[O:5])[CH3:2].C([O-])=O.[NH4+]>CCO.C(O)CC.[OH-].[Pd+2].[OH-]>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH2:18][CH3:19])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([NH2:15])=[CH:10][CH:9]=2)=[O:5])[CH3:2]

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 12148796ethyl 1-ethyl-5-nitro-1H-indole-2-carboxylate

生成物 1

HCID 12148797Ethyl 5-amino-1-ethyl-1H-indole-2-carboxylate収率 90.2%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 9793718EtOH n-PrOH溶媒

実験手順

The 1-ethyl-5-nitro-1H-indole-2-carboxylic acid ethyl ester (59, 19.1 mmol) of step (a) was dissolved in EtOH/n-PrOH (100 mL, 1/1). Palladium hydroxide (1.14 g) and ammonium formate (3.92 g, 62.2 mmol) were added to the above solution. The mixture was heated to reflux for 2 hours. The reaction mixture was cooled to room temperature and the catalyst was filtered off through Celite. The solvent was removed under reduced pressure. The crude product was dissolved in dichloromethane (300 mL) and washed with NaHCO3 (150 ml×2). The organic layer was collected, dried (Na2SO4) and evaporated. The crude product was purified by chromatography to furnish the desired product (4 g, 90%).

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 2 hours
  3. filtrationthe catalyst was filtered off through Celite
  4. customThe solvent was removed under reduced pressure
  5. dissolutionThe crude product was dissolved in dichloromethane (300 mL)
  6. washwashed with NaHCO3 (150 ml×2)
  7. customThe organic layer was collected
  8. dry with materialdried (Na2SO4)
  9. customevaporated
  10. customThe crude product was purified by chromatography

出典と根拠

ORDレコード
ord-0b7a1fdb9017478b9da07b6aa7c15383
出典データセット
uspto-grants-2009_01
特許番号
US07482368B2

反応ノート

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