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Methanol → 5-(2-Hydroxy-benzoylamino)-1-methyl-1H-indole-2-carboxylic acid

HRID 1455844
ノート
印刷プレビュー

反応式

HRID 1455844 の反応式
C(N(C)C(=O)[C@@H](N[C:18]([C:20]1[N:21]([CH3:43])[C:22]2[C:27]([CH:28]=1)=[CH:26][C:25]([NH:29][C:30](=[O:42])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[O:37]CCCC)=[CH:24][CH:23]=2)=[O:19])C1C=CC=CC=1)C1C=CC=CC=1.C[OH:47].O.[OH-].[Li+]>C1COCC1>[OH:37][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=1[C:30]([NH:29][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[N:21]([CH3:43])[C:20]([C:18]([OH:47])=[O:19])=[CH:28]2)=[O:42]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 887MethanolHCID 962WaterHCID 3939Lithium HydroxideHCID 23589009(s)-5-(2-Butoxy-benzoylamino)-1-methyl-1h-indole-2-carboxylic acid {2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl}-amide

生成物 1

HCID 222627095-(2-Hydroxy-benzoylamino)-1-methyl-1H-indole-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 8028
Tetrahydrofuran
溶媒

実験手順

The product of step (a) (2.0 g, 5.26 mM) was dissolved in THF (30 mL), methanol (10 mL), and water (10 mL). The mixture was treated with lithium hydroxide (882 mg, 21.04 mM) and the mixture was stirred at room temperature for 3 hours. The mixture was concentrated to 15 mL and the pH was adjusted to about 3.0 with 1 N HCl. The mixture was extracted 3 times with ethyl acetate (25 mL). The ethyl acetate fractions were combined, dried over MgSO4, filtered and concentrated to provide the title compound.

後処理

  1. concentrationThe mixture was concentrated to 15 mL
  2. extractionThe mixture was extracted 3 times with ethyl acetate (25 mL)
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-0cbdcec9ebab45088a635a825c744f00
出典データセット
uspto-grants-2009_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07482368B2

反応ノート

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