Methyl iodide → HCID 19980329、化合物

反応式

[H-].[Na+].[C:3]([NH:10][C:11]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=1[N+:18]([O-:20])=[O:19])([C:5]([O:7][CH2:8][CH3:9])=[O:6])=[O:4].[CH3:21]I>CN(C=O)C>[C:3]([N:10]([CH3:21])[C:11]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=1[N+:18]([O-:20])=[O:19])([C:5]([O:7][CH2:8][CH3:9])=[O:6])=[O:4]

参加物

実験手順

NaH (1 g, 22 mmol) was added in portions to a stirred solution of N-ethoxalyl-2-nitro-6-methylaniline (5 g, 20 mmol) in DMF (50 ml). Methyl iodide (2 ml, 22 mmol) was thereafter added. The mixture was left overnight at room temperature, whereafter the solvent was removed by evaporation in vacuo. The residue was partitioned between ether and water. The organic phase was washed with water, dried over Na2SO4 and evaporated to give the title compound as an oil.