反応式
[OH:1][CH2:2][CH2:3]NCC(O)CO.C([O:13][C:14](=[O:16])[CH3:15])(=O)C.N1C=CC=CC=1.[CH3:23][C:24](N(C)C)=[O:25]>C(=O)([O-])[O-].[Na+].[Na+]>[CH3:23][C:24]([CH2:3][C:2]([CH2:15][C:14]([OH:13])=[O:16])=[O:1])=[O:25]参加物
実験手順
As in Example 12, the title compound is prepared stepwise by first reacting 5-amino-2,4,6-triiodo-3-N-methylaminocarbonylbenzoyl chloride with 3-(N-2-hydroxyethyl)amino-1, 2-propanediol dissolved in DMAc in the presence of sodium carbonate. The product, 5-amino[N-(2,3,-dihydroxypropyl)-N-(2-hydroxyethyl]-2,4,6-triiodo-3-N-methylaminocarbonylbenzamide, is reacted with acetic anhydride in the presence of pyridine to produce the triacetate, [N-(2-acetoxyethyl)-N-(2,3-diacetoxypropyl)]-5-amino-,4,6-triiodo -3-N-methylaminocarbonylbenzamide. This compound is then reacted with 2,4-dibromobutryl bromide, prepared as in Example 12, Step B, and the product is then cyclized, hydrolyzed, and purified as in Example 12, Steps D and E to produce the final product.
後処理
- customAs in Example 12, the title compound is prepared stepwise
出典と根拠
- ORDレコード
- ord-fc367aa39780419a8b3544359115cef5
- 出典データセット
- uspto-grants-1991_12
- 特許番号
- US05075502
関連ノート
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