Sodium Iodide → HCID 178472996、化合物

HRID 1462927

反応式

HRID 1462927 の反応式
[CH2:1]([O:3][C:4]([N:6]1[CH:10]=[CH:9][N:8]=[CH:7]1)=[O:5])[CH3:2].Cl[CH2:12][C:13]1[CH:25]=[CH:24][C:16]([O:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][CH:14]=1.[I-:26].[Na+]>C(#N)C>[I-:26].[CH2:1]([O:3][C:4]([N+:6]1[CH:10]=[CH:9][N:8]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([O:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:24][CH:25]=2)[CH:7]=1)=[O:5])[CH3:2]

参加物

5

反応物 3

HCID 5238Sodium IodideHCID 87963Ethyl 1H-imidazole-1-carboxylateHCID 4351015(4-Chloromethyl-phenoxy)-acetic acid ethyl ester

生成物 1

HCID 178472996HCID 178472996、化合物収率 100%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

1.4 g of 1-ethoxycarbonylimidazole, 2.5 g of ethyl 4-chloromethylphenoxyacetate and 1.7 g of sodium iodide were added to 5 ml of dry acetonitrile, and the mixture was stirred at room temperature for 6 hours. After completion of the reaction, the insoluble materials were filtered off and the filtrate was concentrated under reduced pressure. The residue was triturated with an adequate amount of dry diethyl ether, the resulting powder was collected by filtration and dried to obtain 4.6 g of 1-ethoxycarbonyl-3-(4-ethoxycarbonylmethoxybenzyl)imidazolium iodide (quantitative yield). Colorless hygroscopic amorphous.

後処理

  1. customAfter completion of the reaction
  2. filtrationthe insoluble materials were filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was triturated with an adequate amount of dry diethyl ether
  5. filtrationthe resulting powder was collected by filtration
  6. customdried

出典と根拠

ORDレコード
ord-f155f51ea6a94ecc9499bbd71347b6f3
出典データセット
uspto-grants-1984_07
特許番号
US04461905

関連ノート

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