OP(O)(O)=O.[C:6]([O-:9])([O-])=O.[K+].[K+].[CH3:12][C:13]([OH:16])(C)C.Cl/C(/[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=C\C>[Ni].O=[Os](=O)(=O)=O.C(OCC)(=O)C.O>[OH:16][C@@H:13]([CH3:12])[C:6]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:9]A divided glass H-cell as described in Example-6.1 which is equipped with a platinum-on-titanium metal anode (5 cm2) and a nickel foil cathode is charged in the cathode compartment with 50 mL of 8% H3PO4 solution and in the anode compartment with K3Fe(CN)6 (1.71 g, 4.5 mmol), K2CO3 (10.35 g, 75.0 mmol) and t-BuOH (45 mL)/water (50 mL), the chiral ligand, PHAL-DHQ (175 mg 0.225 mmol), OsO4 (0.196 M in toluene, 0.077 mL, 0.015 mmol) and Z-1-chloro-1-phenylpropene (6.9 g, 66.6% purity, 30 mmol). The mixture is electrolyzed at 0.4 V (vs ref. Ag/AgCl) at 15° C. until about 4950 coulombs (85% conversion) of electricity is used. After stirring without electricity for 2 hours, the reaction is worked up as in Example 6.1 using ethyl acetate as the extraction solvent to give (S)-2-hydroxypropiophenone as a yollow liquid (6.8 g, 95.1% ee by HPLC analysis on a Chiralcell OD column). The crude product is purified on slica gel eluting with 5-15% ethyl acetate in hexane to give pure (S)-2-hydroxypropiophenone as a pale yellow solid (3.0 g).
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