1-Bromo-2-nitrobenzene → 3'-Methylthio-2-nitrobiphenyl

HRID 1464065ノート

反応式

HRID 1464065 の反応式
[CH3:1][S:2][C:3]1[CH:4]=[C:5](I)[CH:6]=[CH:7][CH:8]=1.[N+:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1Br)([O-:12])=[O:11]>[Cu]>[CH3:1][S:2][C:3]1[CH:4]=[C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N+:10]([O-:12])=[O:11])[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 113411-Bromo-2-nitrobenzeneHCID 107057833-Iodothioanisole

生成物 1

HCID 190892373'-Methylthio-2-nitrobiphenyl

試薬・触媒・溶媒 1

HCID 23978Copper触媒

反応条件

温度
120 °C

実験手順

A mixture of 3-methylthioiodobenzene (30 g), 2-nitrobromobenzene (24 g) and copper powder (23 g) was heated at 120° C. for 34 hours to yield a residue which was purified by chromatography on a silica column eluted with hexane to give 3'-methylthio-2-nitrobiphenyl (m.p. 42°-43° C.).

後処理

  1. customto yield a residue which
  2. customwas purified by chromatography on a silica column
  3. washeluted with hexane

出典と根拠

ORDレコード
ord-e007fcf492314eedb9499ae80300072c
出典データセット
uspto-grants-1994_04
特許番号
US05302720

反応ノート

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