Sodium Carbonate → 3,6-Dichloro-5-{[3-fluoro-5-(trifluoromethyl)phenyl]sulfanyl}-1,2,4-triazine

HRID 1472106ノート

反応式

HRID 1472106 の反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[C:6](Cl)[N:7]=1.[F:10][C:11]1[CH:12]=[C:13]([SH:21])[CH:14]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:16]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1COCC1>[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[C:6]([S:21][C:13]2[CH:14]=[C:15]([C:17]([F:18])([F:19])[F:20])[CH:16]=[C:11]([F:10])[CH:12]=2)[N:7]=1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 122624033,5,6-Trichloro-1,2,4-triazineHCID 670547273-Fluoro-5-(trifluoromethyl)thiophenol

生成物 1

HCID 866688233,6-Dichloro-5-{[3-fluoro-5-(trifluoromethyl)phenyl]sulfanyl}-1,2,4-triazine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3,5,6-trichloro-1,2,4-triazine (3 mmol) in dry THF (30 mL) at −78° C. under nitrogen atmosphere is added 3-fluoro-5-(trifluoromethyl)benzenethiol (3 mmol) and sodium carbonate (3 mmol). The reaction is allowed to reach room temperature and is stirred at room temperature until formation of the desired compound. The solvent is evaporated. The residue is suspended in water and extracted with CH2Cl2. The dichloromethane solution is dried over MgSO4 and evaporated. The residue is chromatographed on a silica gel column.

後処理

  1. customto reach room temperature

出典と根拠

ORDレコード
ord-e599684a16034b8b98a7108bd3de8c07
出典データセット
uspto-grants-2015_04
特許番号
US09012462B2

反応ノート

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