Sodium Hydroxide → HCID 71087699、化合物

HRID 1478895ノート

反応式

HRID 1478895 の反応式
[CH2:1]([N:3]1[C:11]2[CH:10]=[C:9]([C:12]([O:14]C)=[O:13])[N:8]=[CH:7][C:6]=2[C:5]([CH3:16])=[CH:4]1)[CH3:2].[OH-].[Na+]>C1COCC1>[CH2:1]([N:3]1[C:11]2[CH:10]=[C:9]([C:12]([OH:14])=[O:13])[N:8]=[CH:7][C:6]=2[C:5]([CH3:16])=[CH:4]1)[CH3:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 71087757HCID 71087757、化合物

生成物 1

HCID 71087699HCID 71087699、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In a 200-ml round bottom flask, methyl 1-ethyl-3-methyl-1H-pyrrolo[3,2-c]pyridine-6-carboxylate (1N, 6.0 g, 28 mmol) was dissolved in THF (50 ml). To the mixture was added a 2M NaOH (28 ml, 55 mmol) solution. The reaction was stirred at room temperature for 3 hrs. After completion, volatiles were removed and the residue was cooled in an ice bath and neutralized with dilute HCl to pH=4.0-4.5. The aqueous mixture washed with ethyl acetate (2×100 ml) and then lyophilized to give the crude product 1-ethyl-3-methyl-1H-pyrrolo[3,2-c]pyridine-6-carboxylic acid (10) which is used in the next step without further purification.

後処理

  1. customAfter completion, volatiles were removed
  2. temperaturethe residue was cooled in an ice bath
  3. washThe aqueous mixture washed with ethyl acetate (2×100 ml)

出典と根拠

ORDレコード
ord-3c14028d769e4584ab8c145d6cd154f5
出典データセット
uspto-grants-2016_08
特許番号
US09403819B2

反応ノート

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